Celiac Disease Testing: tTG-IgA and Why Gluten Matters

Celiac disease is an immune-mediated intestinal condition triggered by gluten. Chronic diarrhoea, bloating, unexplained iron deficiency or a family history may prompt testing.

Symptoms, causes and key details

Doctors commonly use tissue transglutaminase IgA (tTG-IgA) together with total IgA. Endoscopy and biopsy may be required; selected children may follow specific diagnostic pathways.

Assessment and practical next steps

Do not stop eating gluten before tests without advice; a gluten-free diet can lower antibodies and mask the diagnosis. Share symptoms and family history.

When is urgent help needed?

Severe dehydration, major weight loss or inability to eat requires prompt medical assessment.

Frequently asked question

Can I test after stopping gluten?

Results may be falsely negative; agree a testing plan with your clinician.

This article provides general information, not a personal diagnosis or treatment.

Trusted information source: https://www.niddk.nih.gov/health-information/digestive-diseases/celiac-disease/diagnosis